Horm Res. 2004.
The role of insulin-like growth factor I monitoring in growth hormone-treated children.
Park P, Cohen P.
Division of Endocrinology, Department of Pediatrics, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA.
[ PubMed ]

Abstract: Growth hormone (GH) therapy has evolved rapidly over the past decade, and continuing research has established a clear role for therapeutic GH in a wide spectrum of disorders, including idiopathic GH deficiency (childhood- and adult-onset), Turner syndrome, Prader-Willi syndrome, small-for-gestational age children with failure of catch-up growth, AIDS-related catabolism, children with chronic renal failure, and idiopathic short stature. Although GH is used therapeutically in a wide variety of conditions, actual guidelines regarding the logistics of GH dosing continue to evolve, with data emerging regarding efficacy and safety. This review proposes a role for insulin-like growth factor I measurement in optimizing GH dosing.