Neuropharmacology. 1984 May.
Transient seizure activity induced by acetylcarnitine.
Fariello RG, Zeeman E, Golden GT, Reyes PT, Ramacci T.

Intracerebral injection of L-acetylcarnitine in rats induced interictal and ictal epileptic phenomena with immediate onset, lasting up to 4 h. Pretreatment with systemic atropine prevents all epileptiform phenomena. Local injection of muscimol and THIP abolish ictal events, but not single spikes. L-carnitine induced only ictal discharges with a latency of 40-90 min. Acetylcarnitine epileptogenic properties are probably related to muscarinic agonism. The transition from interictal to ictal events may involve failure of GABAergic mechanisms.

Categories: Year-1984, Carnitine, Neurological, Seizures, GABA