Sleep. 1980.
Impaired sexual maturation associated with sleep apnea syndrome during puberty: a case study.
Mosko SS, Lewis E, Sassin JF.

A 20-year-old hypogonadal man was discovered to have had obstructive sleep apnea syndrome - secondary to hypertrophied tonsils, adenoids, and uvula - spanning the years of puberty. All-night polysomnographic recordings and 24 hr measurements of plasma luteinizing hormone (LH) concentrations (sampling at 20 min intervals) were performed before and after combined tonsillectomy, adenoidectomy, and uvulectomy. Two weeks preoperatively, nocturnal sleep was markedly disturbed by 407 apneic episodes, and the patient was found to be hypogonadotropic. Daytime LH concentrations were in the low-normal range for an adult male, and concentrations fell dramatically during nocturnal sleep. This contrasts with both the sleep-related elevation of LH normally seen in puberty and the adult pattern, where no difference is observed in mean concentrations during waking and sleep. Two week and 6 month postoperative evaluations revealed complete alleviation of the sleep apnea syndrome and normalization of the 24 hr pattern of plasma LH, although LH values remained in the low-normal range. Plasma testosterone concentrations were in the low to low-normal range both pre- and postoperatively. No evidence of continued sexual development, beyond that achieved preoperatively, was observed 20 months after surgery, despite continued relief from apnea. These data suggest that sleep apnea during puberty may impair sexual development by preventing the sleep-related elevation in LH secretion normally observed during a critical period spanning puberty.

Categories: 1980, Respiratory, Sleep-related breathing disorders, Apnea, Obstructive sleep apnea, Luteinizing hormone, Testosterone, Hypogonadism, Sexual development, Puberty